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Home / Primary Antibodies / Polyclonal Antibodies

DNMT3A antibody

SKU : BHA10802478

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Mfr.No.	FNab02484
Background	CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Host	Rabbit
Immunogen	DNA (cytosine-5-)-methyltransferase 3 alpha
Isotype	IgG
Molecular Weight	95 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	DNMT3A2

Uniprot	Q9Y6K1
Gene Id	1788
Research Area	Epigenetics, Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC
Description	ELISA ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab02484.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802478	FNab02484	100ug	$240		Add to Cart

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