CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Clonality
polyclonal
Host
Rabbit
Immunogen
DNA (cytosine-5-)-methyltransferase 3 alpha
Immunogen Region
DNA (cytosine-5-)-methyltransferase 3 alpha
Isotype
IgG
Reactivity
Human, Mouse
Recommended Dilution
IHC: 1:20-1:200
Synonyms
DNMT3A2
Uniprot
Q9Y6K1
Gene Id
1788
Research Area
Epigenetics, Developmental biology, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10773.pdf" target="_blank">Data Sheet</ a>