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Home / Primary Antibodies / Polyclonal Antibodies

DNAJB6 antibody

SKU : BHA10802446

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Mfr.No.	FNab02452
Alternative Names	HSJ2 ; MRJ ; MSJ1
Background	This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Host	Rabbit
Immunogen	DnaJ (Hsp40) homolog, subfamily B, member 6
Isotype	IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HSJ2, MRJ, MSJ1

Uniprot	O75190
Gene Id	10049
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF, WB, IP
Description	ELISA ; IHC ; IF ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Manual	FNab02452.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802446	FNab02452	100ug	$240		Add to Cart

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