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Home / Primary Antibodies / Polyclonal Antibodies

DICER1 antibody

SKU : BHA10802381

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Mfr.No.	FNab02387
Alternative Names	DICER ; HERNA ; KIAA0928
Background	This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Host	Rabbit
Immunogen	dicer 1, ribonuclease type III
Isotype	IgG
Molecular Weight	220-250 kDa
Reactivity	Human, Mouse, Rat, Monkey
Regulatory	RUO
Synonyms	DICER, HERNA, KIAA0928

Uniprot	Q9UPY3
Gene Id	23405
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500 - 1:1000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab02387.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802381	FNab02387	100ug	$240		Add to Cart

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