With DHDDS, forms the dehydrodolichyl diphosphate synthase(DDS) complex, an essential component of the dolichol monophosphate(Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate(IPP) to farnesyl pyrophosphate(FPP) to produce dehydrodolichyl diphosphate(Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum(ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
Categories
Primary Antibodies
Clonality
polyclonal
Description
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
Host
Rabbit
Immunogen
dehydrodolichyl diphosphate synthase
Isotype
IgG
Molecular Weight
34 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
HDS
Antigen
DHDDS
Uniprot
Q86SQ9
Gene Id
79947
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)