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Home / Primary Antibodies / Polyclonal Antibodies

DCLRE1B antibody

SKU : BHA10802261

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Mfr.No.	FNab02267
Alternative Names	SNM1B
Background	5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Categories	Primary Antibodies
Clonality	polyclonal
Description	5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Host	Rabbit
Immunogen	DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)
Isotype	IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	SNM1B

Uniprot	Q9H816
Gene Id	64858
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500-1:2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802261	FNab02267	100ug	$260		Add to Cart

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