Chemokine, CXC Motif, Receptor 6, also known as STRL33 and Bonzo, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al.(1997) mapped the single-copy gene to chromosome 3. Matloubian et al.(2000) found that human and mouse cells expressing the protein showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al.(2001) concluded that the proteinb may be important in the trafficking of effector T cells mediating type-1 inflammation.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of mouse CXCR6 (EDSSKTCSASHNVETTSMFQL) was used as the immunogen for this CXCR6 antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Mouse, Rat
Recombinant
No
Antigen
CXCR6
Uniprot
Q9EQ16
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the CXCR6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
IHC-P, WB
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml