CSPG4, also named as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16 and NG2, is a proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. CSPG4 may inhibit neurite outgrowth and growth cone collapse during axon regeneration. It is cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. CSPG4 may regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. It modulates the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin.
Clonality
polyclonal
Host
Rabbit
Immunogen
chondroitin sulfate proteoglycan 4
Immunogen Region
chondroitin sulfate proteoglycan 4
Isotype
IgG
Molecular Weight
270kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500
Synonyms
CSPG4, HMW MAA, MCSP, MCSPG, MEL CSPG, MSK16, NG2
Uniprot
Q6UVK1
Gene Id
1464
Research Area
Developmental biology, Signal Transduction, Cardiovascular, Stem Cells, Neuroscience
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10522.pdf" target="_blank">Data Sheet</ a>