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Home / Primary Antibodies / Monoclonal Antibodies

CREST antibody

SKU : BHA10801966

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Mfr.No.	FNab01972
Background	Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).
Categories	Primary Antibodies
Clonality	monoclonal
Host	Mouse
Immunogen	synovial sarcoma translocation gene on chromosome 18-like 1
Isotype	IgG1
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CREST, KIAA0693, LP2261, SS18 like protein 1, SS18L1, SYT homolog 1

Uniprot	O75177
Clone No	7A7
Research Area	Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:1000-1:6000

Manual	FNab01972.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801966	FNab01972	100ug	$300		Add to Cart

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