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Home / Primary Antibodies

COX2 Antibody / PTGS2 (V8996)

SKU : BHA17119519

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NSJ Bioreagents

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Mfr.No.	V8996, V8996-20UG, V8996-100UG
Clonality	Monoclonal (mouse origin)
Description	Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (COX2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and COX2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. COX2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Mouse
Immunogen Region	A portion of amino acids 442-572 was used as the immunogen for the COX2 antibody.
Isotype	Mouse IgG2a, kappa
Species Reactivity	Human
Note	Optimal dilution of the COX2 antibody should be determined by the researcher.

Uniprot	P35354

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17119519-1	V8996-20UG	20ug	$219		Add to Cart
BHA17119519-2	V8996-100UG	100ug	$499		Add to Cart

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