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Home / Primary Antibodies / Polyclonal Antibodies

COMT antibody

SKU : BHA10801850

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Mfr.No.	FNab01856
Background	Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Host	Rabbit
Immunogen	catechol-O-methyltransferase
Isotype	IgG
Molecular Weight	28 kDa, 32 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	P21964
Gene Id	1312
Research Area	Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF, FC, IP, WB
Description	ELISA ; IHC ; IF ; FC ; IP ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab01856.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801850	FNab01856	100ug	$240		Add to Cart

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