This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).
Host
Rabbit
Immunogen
collectin sub-family member 11
Isotype
IgG
Molecular Weight
35 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
CL K1, CL K1 I, CL K1 II, CL K1 IIa, CL K1 IIb, CLK1, COLEC11, Collectin 11, Collectin kidney protein 1, collectin sub family member 11
Uniprot
Q9BWP8
Gene Id
78989
Research Area
Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)