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Home / Primary Antibodies / Polyclonal Antibodies

CLSPN antibody

SKU : BHA10801770

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Mfr.No.	FNab01775
Background	Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Host	Rabbit
Immunogen	claspin homolog(Xenopus laevis)
Isotype	IgG
Molecular Weight	240 kDa
Reactivity	Human
Regulatory	RUO

Uniprot	Q9HAW4
Gene Id	63967

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801770	FNab01775	100ug	$240		Add to Cart

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