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Home / Primary Antibodies / Polyclonal Antibodies

CDK4 antibody

SKU : BHA10801552

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Mfr.No.	FNab01557
Background	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Host	Rabbit
Immunogen	cyclin-dependent kinase 4
Isotype	IgG
Molecular Weight	32 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3

Uniprot	P11802
Gene Id	1019
Research Area	Cell Division and Proliferation, Metabolism, Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, FC, IP
Description	ELISA ; WB ; IHC ; IF ; FC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100

Manual	FNab01557.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801552	FNab01557	100ug	$240		Add to Cart

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