Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Clonality
polyclonal
Host
Rabbit
Immunogen
cell division cycle 20 homolog
Immunogen Region
cell dIVIsion cycle 20 homolog
Isotype
IgG
Molecular Weight
55 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Synonyms
CDC20, CDC20A, p55CDC
Uniprot
Q12834
Gene Id
991
Research Area
Cell Division and Proliferation, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09997.pdf" target="_blank">Data Sheet</ a>