The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
Clonality
polyclonal
Host
mouse
Immunogen
CD8a molecule
Immunogen Region
transducin-like enhancer of split 1
Isotype
IgG1
Molecular Weight
30 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms
CD8, Leu2, MAL, p32
Uniprot
P01732
Gene Id
925
Clone No
2B9
Form
liquid
Purification
protein A+G purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10855.pdf" target="_blank">Data Sheet</ a>