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Home / Primary Antibodies / Polyclonal Antibodies

CD68 antibody

SKU : BHA10801486

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Mfr.No.	FNab01491
Background	This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Host	Rabbit
Immunogen	CD68 molecule
Isotype	IgG
Molecular Weight	Refer to figures
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Cell membrane
Synonyms	CD68, CD68 molecule, DKFZp686M18236, GP110, Macrosialin, SCARD1

Uniprot	P34810
Gene Id	968
Research Area	Stem Cells, Immunology, Cancer, Neuroscience
Weight	37kDa,observed 60kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC

Description

ELISA ; IHC

Dilution

IP	1:200-1:1000
IHC	1:50-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab01491.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801486	FNab01491	100ug	$240		Add to Cart

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