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Home / Primary Antibodies / Polyclonal Antibodies

CD44 antibody

SKU : BHA10801477

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Mfr.No.	FNab01482
Alternative Names	LHR ; MDU2 ; MDU3 ; MIC4
Background	The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
Host	Rabbit
Immunogen	CD44 molecule (Indian blood group)
Isotype	IgG
Molecular Weight	79 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	LHR, MDU2, MDU3, MIC4

Uniprot	P16070
Gene Id	960
Research Area	Stem Cells, Immunology, Cardiovascular, Cancer

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP, FC, IF
Description	ELISA ; WB ; IHC ; IP ; FC ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab01482.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801477	FNab01482	100ug	$260		Add to Cart

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