The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
CD3e molecule, epsilon (CD3-TCR complex)
Isotype
IgG
Molecular Weight
23 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
CD3, CD3 epsilon, CD3E, CD3-epsilon, T3E, TCRE
Uniprot
P07766
Gene Id
916
Research Area
Cancer, Immunology, Signal Transduction
Weight
23kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)