CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells.
Clonality
polyclonal
Host
Rabbit
Immunogen
CD3e molecule, epsilon (CD3-TCR complex)
Immunogen Region
CD3e molecule, epsilon (CD3-TCR compleX)
Isotype
IgG
Molecular Weight
23-25 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500 - 1:2000
Synonyms
CD3, CD3 epsilon, CD3E, CD3-epsilon, T3E, TCRE
Uniprot
P07766
Gene Id
916
Research Area
Cancer, Immunology, Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10016.pdf" target="_blank">Data Sheet</ a>