The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
syndecan 1
Isotype
IgG
Molecular Weight
32 kDa, 85-120 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
CD138, SDC, SYND1, syndecan
Uniprot
P18827
Gene Id
6382
Research Area
Signal Transduction, Cardiovascular, Immunology, Cancer, Stem Cells, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)