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Home / Primary Antibodies / Polyclonal Antibodies

CBLB antibody

SKU : BHA10801313

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Mfr.No.	FNab01318
Alternative Names	RNF56
Background	CBLB (Cbl proto-oncogene B, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with CBLB include cannabis dependence. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is CBLC.
Categories	Primary Antibodies
Clonality	polyclonal
Description	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Host	Rabbit
Immunogen	Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	RNF56

Uniprot	Q13191
Gene Id	868
Research Area	Epigenetics, Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF
Description	ELISA ; WB ; IHC ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab01318.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801313	FNab01318	100ug	$240		Add to Cart

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