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Home / Primary Antibodies / Monoclonal Antibodies

Caspase 8 antibody

SKU : BHA10801289

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Mfr.No.	FNab01294
Alternative Names	Apoptoticcysteineprotease ; ApoptoticproteaseMch5 ; Casp8 ; CASP8 ; Caspase8 ; Caspase8/p18 ; Caspase8 ; FADDlikeICE ; FLICE ; ICElikeapoptoticprotease5 ; MACH
Background	Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro-and cleaved-caspase 8.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	monoclonal
Description	Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 66093-1-AP can recognize pro- and cleaved-caspase 8.
Host	Mouse
Immunogen	caspase 8, apoptosis-related cysteine peptidase
Isotype	IgG1
Molecular Weight	50-55 kDa, 25-32 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5

Uniprot	Q14790
Clone No	2C2
Research Area	Metabolism
Weight	30-60kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF, IP

Description

ELISA ; IHC ; WB ; IF ; IP

Dilution

WB	1:500-1:5000
IP	1:200-1:2000
IHC	1:100-1:400
IF	1:50-1:500

Tested Application

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:100-1:400; IF: 1:50-1:500

Manual	FNab01294.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801289	FNab01294	100ug	$260		Add to Cart

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