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Home / Primary Antibodies / Polyclonal Antibodies

Caspase 3 antibody

SKU : BHA10801284

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Mfr.No.	FNab01289
Alternative Names	Apopain ; CASP3 ; CASP3 ; Caspase3 ; Caspase3/p17 ; Caspase3 ; CPP32 ; CPP32 ; CPP32B ; CysteineproteaseCPP32 ; ProteinYama
Background	Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-\|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.
Host	Rabbit
Immunogen	caspase 3, apoptosis-related cysteine peptidase
Isotype	IgG
Molecular Weight	32-35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1

Uniprot	P42574
Research Area	Metabolism
Weight	32kDa,observed 32-35 kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF, IP

Description

ELISA ; IHC ; WB ; IF ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:50-1:500
IF	1:20-1:200

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200

Manual	FNab01289.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801284	FNab01289	100ug	$240		Add to Cart

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