This gene encodes a member of the cysteine-aspartic acid protease(caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
caspase 2, apoptosis-related cysteine peptidase
Isotype
IgG
Molecular Weight
50 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
CASP 2, CASP2, Caspase 2,ICH 1L, ICH 1L/1S, ICH1, NEDD 2, NEDD2, Protease ICH 1
Uniprot
P42575
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)