CASP2(Caspase-2) is also named as ICH1, NEDD2 and belongs to the peptidase C14A family.It is involved in the activation cascade of caspases responsible for apoptosis execution and might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.It has 2 isoforms produced by alternative splicing and can exists almost as a dimer in solution(PMID:15865942).This antibody can recognize the 32 kDa pro-caspase 2 as well as 18 kDa cleaved-caspase 2.
Clonality
monoclonal
Host
Mouse
Immunogen
Caspase 2
Immunogen Region
Caspase 2
Isotype
IgG1
Molecular Weight
18, 32, 50 kDa
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:6000
Synonyms
CASP 2, CASP2, Caspase 2, Caspase2, ICH 1L, ICH 1L/1S, ICH1, NEDD 2, NEDD2, Protease ICH 1
Uniprot
P42575
Gene Id
835
Clone No
2B10
Research Area
Immunology, Signal Transduction, Neuroscience
Form
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:1000-1:6000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab098281.pdf" target="_blank">Data Sheet</ a>