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Home / Primary Antibodies / Polyclonal Antibodies

Caspase 1 antibody

SKU : BHA10801279

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Mfr.No.	FNab01284
Alternative Names	CASP1 ; CASP1 ; Caspase1 ; Caspase1/p20/p10 ; Caspase1 ; ICE ; IL1betaconvertingenzyme ; IL1BC ; IL1BC ; IL1BCE ; Interleukin1betaconvertase
Background	CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.
Categories	Primary Antibodies
Clonality	polyclonal
Description	CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.
Host	Rabbit
Immunogen	caspase 1, apoptosis-related cysteine peptidase(interleukin 1, beta, convertase)
Isotype	IgG
Molecular Weight	45-47 kDa, 30 kDa, 35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45

Uniprot	P29466
Gene Id	834
Research Area	Metabolism
Weight	45kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF

Dilution

WB	1:500-1:5000
IHC	1:100-1:400
IF	1:10-1:100

Tested Application

WB: 1:500-1:2000,IHC: 1:20-1:200

Manual	FNab01284.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801279	FNab01284	100ug	$260		Add to Cart

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