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Home / Primary Antibodies / Polyclonal Antibodies

CAPNS1 antibody

SKU : BHA10801245

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Mfr.No.	FNab01250
Alternative Names	CAPN4 ; CAPNS
Background	This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Host	Rabbit
Immunogen	calpain, small subunit 1
Isotype	IgG
Molecular Weight	28 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CAPN4, CAPNS

Uniprot	P04632
Gene Id	826
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab01250.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801245	FNab01250	100ug	$240		Add to Cart

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