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Home / Primary Antibodies / Polyclonal Antibodies

C4BPB antibody

SKU : BHA10801109

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Mfr.No.	FNab01114
Background	This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Host	Rabbit
Immunogen	complement component 4 binding protein, beta
Isotype	IgG
Molecular Weight	40-45 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	C4b binding protein beta chain, C4BP, C4BPB

Uniprot	P20851
Gene Id	725
Research Area	Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100

Manual	FNab01114.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801109	FNab01114	100ug	$240		Add to Cart

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