Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex(C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Host
Rabbit
Immunogen
complement component 4 binding protein, alpha
Isotype
IgG
Molecular Weight
70 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
C4BP
Uniprot
P04003
Gene Id
722
Research Area
Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)