Complement C4, a component of the classical complement pathway, has an important role in innate immune function. C4 protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains (molecular wights 95, 78, and 31 kDa) prior to secretion. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. This antibody can recognize C4 precursor, C4 alpha chain, C4b, and C4d.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
complement component 4A(Rodgers blood group)
Isotype
IgG
Molecular Weight
95 kDa
Reactivity
Human
Regulatory
RUO
Uniprot
P0C0L4
Gene Id
720
Research Area
Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)