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Home / Primary Antibodies / Polyclonal Antibodies

BUB3 antibody

SKU : BHA10800983

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Mfr.No.	FNab00988
Background	Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule(K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome(APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Host	Rabbit
Immunogen	budding uninhibited by benzimidazoles 3 homolog(yeast)
Isotype	IgG
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	O43684
Gene Id	9184
Research Area	Cell Division and Proliferation

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IF
Description	ELISA ; IF
Tested Application	IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800983	FNab00988	100ug	$260		Add to Cart

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