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Home / Primary Antibodies / Polyclonal Antibodies

BUB1 antibody

SKU : BHA10800982

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Mfr.No.	FNab00987
Alternative Names	BUB1L
Background	This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Host	Rabbit
Immunogen	budding uninhibited by benzimidazoles 1 homolog (yeast)
Isotype	IgG
Molecular Weight	133 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BUB1L

Uniprot	O43683
Gene Id	699
Research Area	Cell Division and Proliferation, Developmental biology, Cancer, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IF, WB
Description	ELISA ; IF ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00987.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800982	FNab00987	100ug	$240		Add to Cart

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