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Home / Primary Antibodies / Polyclonal Antibodies

BIN1 antibody

SKU : BHA10800892

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Mfr.No.	FNab00897
Alternative Names	AMPHL
Background	This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Categories	Primary Antibodies
Clonality	polyclonal
Description	May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Host	Rabbit
Immunogen	bridging integrator 1
Isotype	IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	AMPHL

Uniprot	O00499
Gene Id	274
Research Area	Developmental biology, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

Manual	FNab00897.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800892	FNab00897	100ug	$240		Add to Cart

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