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Home / Primary Antibodies / Polyclonal Antibodies

BHLHE40 antibody

SKU : BHA10800883

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Mfr.No.	FNab00888
Alternative Names	BHLHB2 ; 43435 ; SHARP2 ; STRA13
Background	This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
Host	Rabbit
Immunogen	basic helix-loop-helix family, member e40
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BHLHB2, DEC1, SHARP2, STRA13

Uniprot	O14503
Gene Id	8553
Research Area	Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab00888.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800883	FNab00888	100ug	$240		Add to Cart

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