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Home / Primary Antibodies / Polyclonal Antibodies

BCL2 antibody

SKU : BHA10800834

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Mfr.No.	FNab00839
Background	This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Host	Rabbit
Immunogen	B-cell CLL/lymphoma 2
Isotype	IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, Oncogene B cell leukemia 2

Uniprot	P10415
Gene Id	596
Research Area	Cancer, Immunology, Cardiovascular, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP, IHC, FC
Description	ELISA ; WB ; IP ; IHC ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200

Manual	FNab00839.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800834	FNab00839	100ug	$240		Add to Cart

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