Involved in adaptive immune response(PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1(PubMed:18264101).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Host
Rabbit
Immunogen
B-cell CLL/lymphoma 10
Isotype
IgG
Molecular Weight
32kd
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
BCL10, Cellular homolog of vCARMEN, CLAP, CARMEN, CARD like apoptotic protein
Uniprot
O95999
Gene Id
8915
Research Area
Immunology, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)