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Home / Primary Antibodies / Polyclonal Antibodies

BAX antibody

SKU : BHA10800804

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Mfr.No.	FNab00809
Alternative Names	BCL2L4
Background	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Host	Rabbit
Immunogen	BCL2-associated X protein
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BCL2L4, Apoptosis regulator BAX, BAX

Uniprot	Q07812
Gene Id	581
Research Area	Developmental biology, Cancer, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200

Manual	FNab00809.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800804	FNab00809	100ug	$260		Add to Cart

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