Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Categories
Primary Antibodies
Clonality
monoclonal
Description
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Host
Mouse
Immunogen
BCL2-associated X protein
Isotype
IgG2a
Molecular Weight
21 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
BCL2L4
Uniprot
Q07812
Gene Id
581
Clone No
5F4
Research Area
Developmental biology, Cancer, Neuroscience
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)