Controls V(D)J recombination during T-cell development by repressing T-cell receptor(TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta(S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).
Host
Rabbit
Immunogen
BTG3 associated nuclear protein
Isotype
IgG
Molecular Weight
56kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
BANP, BEND1, Protein BANP, SMAR1, SMARBP1
Antigen
BANP
Uniprot
Q8N9N5
Gene Id
54971
Research Area
Developmental biology, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)