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Home / Primary Antibodies / Polyclonal Antibodies

BAD antibody

SKU : BHA10800779

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Mfr.No.	FNab00784
Alternative Names	BBC6 ; BCL2L8
Background	The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Host	Rabbit
Immunogen	BCL2-associated agonist of cell death
Isotype	IgG
Molecular Weight	16 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BBC6, BCL2L8

Uniprot	Q92934
Gene Id	572
Research Area	Cardiovascular, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Manual	FNab00784.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800779	FNab00784	100ug	$240		Add to Cart

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