The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Clonality
polyclonal
Host
Rabbit
Immunogen
BCL2-associated agonist of cell death
Immunogen Region
BCL2-associated agonist of cell death
Isotype
IgG
Molecular Weight
18-25 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500 - 1:2000
Synonyms
BBC6, BCL2L8
Uniprot
Q92934
Gene Id
572
Research Area
Cardiovascular, Neuroscience
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10244.pdf" target="_blank">Data Sheet</ a>