Responsible for the proteolytic processing of the amyloid precursor protein(APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Host
Rabbit
Immunogen
beta-site APP-cleaving enzyme 2
Isotype
IgG
Molecular Weight
60 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
AEPLC, ALP56, ASP21
Uniprot
Q9Y5Z0
Gene Id
25825
Research Area
Metabolism, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)