Responsible for the proteolytic processing of the amyloid precursor protein(APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Clonality
polyclonal
Host
Rabbit
Immunogen
beta-site APP-cleaving enzyme 1
Immunogen Region
beta-site APP-cleaVIng enzyme 1
Isotype
IgG
Molecular Weight
50-55 kDa
Reactivity
Human, Rat
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms
BACE, KIAA1149
Uniprot
P56817
Gene Id
23621
Research Area
Metabolism, Neuroscience
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10412.pdf" target="_blank">Data Sheet</ a>