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Home / Primary Antibodies / Polyclonal Antibodies

BAAT antibody

SKU : BHA10800775

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Mfr.No.	FNab00780
Background	Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids(choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes(primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum(secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation(secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long-and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A(CoASH), and conjugates glycine to these acyl-CoAs.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
Host	Rabbit
Immunogen	bile acid Coenzyme A: amino acid N-acyltransferase(glycine N-choloyltransferase)
Isotype	IgG
Molecular Weight	50kd
Reactivity	Human
Regulatory	RUO

Uniprot	Q14032
Gene Id	570
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC
Description	ELISA ; WB ; IF ; IHC
Tested Application	WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800775	FNab00780	100ug	$240		Add to Cart

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