This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Clonality
polyclonal
Host
Rabbit
Immunogen
ATP7B
Immunogen Region
ATP7B
Isotype
IgG
Molecular Weight
150 kDa
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500 - 1:2000; IF: 1:50 - 1:200
Synonyms
PWD, WC1, WD, WND
Uniprot
P35670
Gene Id
540
Research Area
Signal Transduction, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IF: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09849.pdf" target="_blank">Data Sheet</ a>