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Home / Primary Antibodies / Polyclonal Antibodies

ATG12 antibody

SKU : BHA10800662

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Mfr.No.	FNab00667
Alternative Names	APG12 ; APG12L
Background	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Host	Rabbit
Immunogen	ATG12 autophagy related 12 homolog
Isotype	IgG
Molecular Weight	48-50kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	APG12, APG12L

Uniprot	O94817
Gene Id	9140
Research Area	Epigenetics, Immunology, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF
Description	ELISA ; WB ; IHC ; IF
Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800662	FNab00667	100ug	$240		Add to Cart

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