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Home / Primary Antibodies / Polyclonal Antibodies

ATF6B antibody

SKU : BHA10800660

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Mfr.No.	FNab00665
Alternative Names	CREBL1 ; G13
Background	The endoplasmic reticulum (ER)-transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR). The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms(60,80kd )(PMID: 11256944)
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
Host	Rabbit
Immunogen	activating transcription factor 6 beta
Isotype	IgG
Molecular Weight	110 kDa, 60 kDa, 80 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CREBL1, G13

Uniprot	Q99941
Gene Id	1388
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:1000-1:4000; IP:1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800660	FNab00665	100ug	$240		Add to Cart

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