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Home / Primary Antibodies / Polyclonal Antibodies

ATF6 antibody

SKU : BHA10800659

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Mfr.No.	FNab00664
Background	Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC(GA)-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC(GA)-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Host	Rabbit
Immunogen	activating transcription factor 6
Isotype	IgG
Molecular Weight	90 kDa
Reactivity	Human, Rat, Mouse
Regulatory	RUO
Synonyms	ATF6, ATF6 alpha, ATF6A

Uniprot	P18850
Gene Id	22926
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC, IP
Description	ELISA ; WB ; IF ; IHC ; IP
Tested Application	WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab00664.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800659	FNab00664	100ug	$240		Add to Cart

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