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Home / Primary Antibodies / Polyclonal Antibodies

ATF6 antibody

SKU : BHA10810359

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Mfr.No.	FNab10404
Background	Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed 50kd cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC(GA)-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC(GA)-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Clonality	polyclonal
Host	Rabbit
Immunogen	activating transcription factor 6
Immunogen Region	actIVating transcription factor 6
Isotype	IgG
Molecular Weight	50 kDa,100 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:200-1:2000
Synonyms	ATF6, ATF6 alpha, ATF6A

Uniprot	P18850
Gene Id	22926
Research Area	Signal Transduction, Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10404.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810359	FNab10404	100ug	$240		Add to Cart

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